口腔外科領域におけるセフタジジム (モダシン®) の基礎的検討

概要

論文の詳細を見る
We studied in-vitro antibiotic activity against isolates from oral infections and also distribution to oral tissues after administration of Ceftazidime (CAZ, Modacin®), and following results were obtained. An 80% MIC level of Ceftazidime was measured against a total of 181 strains isolated from 39 clinical cases with oral infections. The peak MIC level was 1.56 μg/ml. Concentration of Ceftazidime on human oral tissues after 1 g administration in the gum and cyst wall ranged from 10 to 50% of the serum level at highest. The peak concentration in bone was about 14.3% of the serum level, which was relatively lower than that in the gum and cyst wall. The half life of serum concentration was about 99 minutes. The above results suggest that ceftazidime was useful in chemotherapy of oral infections diseases.