ラット星状神経節相当部半導体レーザー照射時の周囲組織に対する影響 (安全性試験)

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In this experiment, we have studied macroscopically and histopathologically the effect of diode laser (Ga-Al-As, 810 nm) irradiation after a single application continuous application, and the time course after completing continuous irradiation, on the tissues surrounding the stellate ganglion of rats.<BR>Single irradiation: The submandibular gland, thyroid and common carotid artery of rats were directly irradiated by a diode laser at 300, 500 and 700 mW for 10 or 20 min. No abnormalities of irradiated areas were observed macroscopically or histopathologically.<BR>Continuous irradiation: Irradiation was given for 20 min at 300, 500 or 700 mW to the skin surrounding the rat's stellate ganglion, every other day (3 times/week) for 2 weeks (total six times). The skin of the irradiated areas was observed macroscopically, before, immediately after, and 24 hours after irradiation. No changes were detected at 300 and 500 mW either macroscopically or histopathologically. At 700 mW, erythema and edema were observed on the skin which had been irradiated 2 or 3 times. By the end of six applications of continuous irradiation, crust formation was observed in 20/28 (71. 5%) rats.<BR>Time course after continuous irradiation: Macroscopic and histopathological examinations of the skin, submandibular gland, thyroid and common carotid artery were made immediately after, and 24 hours, 3 days, 1 week, 2 weeks, 1 month and 6 months after continuous irradiation. The crusts on the skin at 700 mW remained 3 days after completing irradiation. After 1 week, the crusts had almost completely disappeared. After 2 weeks, no abnormalities were observed. Histopathological observation of the skin showed the same tendency. No changes were detected at 700 mW in the submandibular gland, thyroid or common carotid artery.
社団法人日本口腔外科学会の論文

ラット星状神経節相当部半導体レーザー照射時の周囲組織に対する影響 (安全性試験)

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