Gd-DTPA (ガドペンテト酸ジメグルミン) による顎内障のMRI診断

概要

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Magnetic resonance (MR) imaging was performed in five internal derangement of temporomandibular joint (TMJ) patients, before and after intravenous administration of gadolinium-DTPA (Gd-DTPA) as a contrast agent. MR imaging was performed with a O.5 tesla unit (VISTA MR; PICKER INTERNATIONAL) using a surface coil. We obtained multiple 5 mm sagital images with open and closed jaw positions. Precontrast proton density images were obtained with a repetition time (TR) of 1, 000 msec and an echo time (TE) of 40 msec (TR/TE=1, 000/40). Gd-DTPA was administered intravenously in a dose of 0.2 m<I>l</I> per kilogram of body weight. After the injection, postcontrast Ti weighted images (500/20) or postcontrast proton density images (1, 000/40) were obtained.<BR>In the postcontrast Ti weighted images, the soft tissue surrounding the articular disk was enhanced and it provided helpful information for assessing the disk position. On the other hand, there was no effect of the contrast agent in the postcontrast proton density images. None of the patients experienced allergic reactions or other side effects. Gd-DTPA appeared to be a safe and effective contrast agent for MR imaging with Ti weighted images. However, compared with our usual imaging of the TMJ, the imaging did not indicate greater MR sensitivity for detecting the articular disk by means of Gd-DTPA enhancement.