上顎に生じた平滑筋肉腫の1例

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Oral leiomyosarcoma has been reported on only 21 cases in the literatures. An additional case of leiomyosarcoma of the maxilla is presented. A 32-year-old woman was reffered to our department from a certain medical college hospital. The pathological diagnosis on the biopsy stained with hematoxilin-eosin at the hospital was the poorly differentiated fibrosarcoma. Surgical resection was abandoned because the tumor invaded the left maxilla extensively from the palatal shelf to the base of skull. Chemotherapy with Adriamycin and Endoxan was performed, and the growth of tumor seemed to be suppressed. However the patient died in cachectic state 22 months after the onset. An autopsy demonstrated diffuse infiltration of the tumor into the medial cranial foxa and metastases in the lungs, liver, right cardiac ventricle and diaphragm. Submandibular and cervical lymphnode were free from metastasis. The autopsy specimen stained with Masson's trichrom, Azan and van Gieson revealed the characteristic structure showing which derived from smooth muscle cell. The diagnosis was ascertained as the leiomyosarcoma. The twenty-two previously reported cases of the oral leiomyosarcoma involving our case are reviewed, and the clinical features and the therapy on the tumor are discussed. The specific staining methods are useful in the diagnosis of this tumor. It is suggested that chemotherapy with Adriamycin is useful to enhance the effect of surgical resection and also to reserve the radical neck dissection after the manifestation of the regional lymphnode metastasis.
社団法人日本口腔外科学会の論文

上顎に生じた平滑筋肉腫の1例

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