A case of malignant melanoma of the palate recurring after an 11-year interval.

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This paper describes a rare case of malignant melanoma of the palate recurring after an 11-year interval. A 66-year-old female presented in September 1980 with a pigmented tumor on the palate. Oral examination revealed a 14 × 7 mm black nodule with an adjacent brownish-black plaque and a light brown macular lesion. There were no enlarged cervical lymph nodes. Under the clinical diagnosis of malignant melanoma (stage I), she underwent surgical excision and adjuvant immunochemotherapy with DTIC, ACNU, VCR and OK-432. Histological examination of the operation material revealed acral lentiginous melanoma (ALM) type. She was clinically free from the tumor for 11 years. In September 1991, an amelanotic small nodule was found near the operation scar. A diagnosis of malignant melanoma was obtained by excisional biopsy. She underwent radical neck dissection because of late neck metastasis in April 1992. She is now free from the tumor one year after the last operation. This case is considered to be very rare because of the long interval to recurrence and the unique findings of the recurrent tumor.