Lactobacillus acidophilusによるMannitolの代謝

概要

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The lactic acid bacterium, Lactobacillus acidophilus IFO-3831 consumed glucose preferentially when cultured aerobically in medium containing glucose and mannitol. Mannitol was not utilized until glucose had been exhausted from the medium. In medium containing only glucose, the cells lost activity more rapidly than in medium containing glucose and mannitol, in which acid formation continued even after the glucose had been exhausted. From the lactate recovery, mannitol catabolism appeared close to be homo fermentation. The activity of mannitol-l-phosphate dehydrogenase (M1PDh) during the mannitol utilization stage resulted in a 7-fold increase of the glucose utilization stage. This suggested that synthesis of M1PDh was repressed by glucose. Under anaerobic conditions, sequential utilization of mannitol was not observed, and the activity of M1PDh was low. These results suggested that the induction of M1PDh was dependent on the existence of glucose and oxygen.
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