3-オキソグルタル酸エステルのアルキル化-2-(3-オキソグルタル酸エステル誘導体の研究-2-)

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The selective alkylation of ethyl 3-oxoglutarate was achieved through its Mg-complex prepared from a normal coordinate treatment with Mg (OEt)2. The structural elucidation of this complex was substantiated by comparison of Cu and Mg chelate compounds prepared from acetylacetone and ethyl acetoacetate. Mg-complex of ethyl 3-oxoglutarate reacted with alkyl halides (RX) in the presence of Mg (OEt)2 or NaOEt as basic catalyst, followed by hydrolysis with hydrochloric acid to give ethyl 2-R-3-oxoglutarate (yield, 78_??_80%). Moreover, the synthesis of ethyl 2-R-4-R'-3-oxoglutarate from ethyl 2-R-3-oxoglutarate can be conducted successfully by using alkyl halides (R'X) in the presence of NaOEt as catalyst (yield, 81_??_82%).
社団法人日本農芸化学会の論文