Effect of Medium Chain Triglyceride (MCT) on Contraction of the Gallbladder

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1) A patient, 46-year-old man, with liver cirrhosis and a large stone in the common bile duct, who had been under severe control of dietary fats for a long time, was given tricaprilic acid triglyceride (MCT) instead of fatty meal. During four months' administration of MCT his body weight increased from 46.5kg to 53.5kg and his troubles such as intermittent high fever and abdominal pain attack occurred less frequently than before, so that a less contractive effect of MCT on the gallbladder was presumed.2) To ascertain this presumption, 22 subjects showing positive cholecystogram with Telepaque were studied as follows. Half of them was given MCT as the contract agent of the gallbladder and the other half was given cotton seed oil, one of long chain triglyceride (LCT).Cholecystographic examination was performed in three steps in each case; the first was carried out by an ordinary technique with Telepaque. Immediately after that, MCT or LCT was given, followed by the second shot 40 minutes later. Yolk tablets were then given and the third was carried out further 40 minutes later. The spell of the gallbladder shadow on each upright spot film was measured. These results indicate that the gallbladder is less influenced by MCT than by LCT regarding to its contraction.3) Based on the above findings, Meulengracht value in duodenal fluid was examined in ten subjects using MCT or LCT as the contract agent. It was also shown by this method that MCT was lower than LCT in the contracting potency.4) In conclusion, MCT have far less contractive effect on the gallbladder and is useful in the management of patients with biliary disturbances.
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Effect of Medium Chain Triglyceride (MCT) on Contraction of the Gallbladder

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