Hepatic protein synthesis rate as an index of hepatic functional reserve in human liver.

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Hepatic protein synthesis rate (HPS) in human livers were measured to evaluate hepatic functional reserve. HPS of 34 patients who underwent operations were studied and were divided into 4 groups. Normal liver (n=7), obstructive jaundice (n=9), liver cirrhosis (n=8) and other hepatic dysfunction (n=10). HPS in normal liver was 6.9±3.0nmol/mg wet wt./10min. HPS in obstructive jaundice liver was 17.1±10.3, and HPS in liver cirrhosis was 47.5±17.8. There were significant differences among these three groups. HPS correlated well with cholinesterase (r=-0.6533, P<0.01) and ICGR15 (r=0.7315, P<0.01).In 15 patients who received hepatectomy, relations between HPS and postoperative complication were studied. There were no complications in patients whose HPS were less than 20nmol/mg wet wt./10min. in major hepatic resection and in patient whose HPS were less than 40 in a segmentectomy. Even if HPS were elevated, the operations were safe in subsegmentectomy and partial hepatectomy. So HPS would be one of the good indices to evaluate hepatic functional reserve.
財団法人日本消化器病学会の論文