Sialylated Lewisx and sialylated Lewisa as tumor-associated carbohydrate antigens in sera of patients with gastric cancer. Usefulness of combination assay of these two antigens.:usefulness of combination assay of these two antigens

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Sialylated Lewisx and sialylated Lewisa antigens, which are structural isomer each other, were serologically tested to determine the clinicopathological differences and correlation between two antigens, and were also compared with thoses of serum CEA in 141 patients with gastric cancer. Percent positives in sialylated Lewisa, CEA and sialylated Lewisx showed 26.9%, 21.8% and 17.0% respectively. Percent positive of sialylated Lewisx correlated with degree of liver metastasis and peritoneal dissemination. Therefore, it is emphasized that the role of sialylated Lewisx is characteristics of detecting a presence of liver matastasis and/or peritoneal dissemination. On the other hand, sialylated Lewisa showed high percent positive in cases which had lymph nodes metastasis and mucinous or papillary adenocarcinomas. These two carbohydrate antigens indicated no correlation (r=0.062) in the spectrum of sera. It is suggested that combination assay of sialylated Lewisx and sialylated Lewisa is useful in detecting many gastric cancer patients including CEA-egative one.
財団法人日本消化器病学会の論文