Abnormal bile acid metabolism in patients with ileal disease and ileal resection-effect of oral ursodeoxycholic acid administration.

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Upper intestinal content was collected after giving a test meal and analyzed. In patients with ileal disease and with ileal resection, total bile acids concentration was reduced and the percentage of the total lipid in the micellar phase was decreased. It was thought that these reduction may cause fat malabsorption.A trial of bile acid replacement with ursodeoxycholic acid (UDCA) was undertaken in these patients. After one month of oral UDCA administration (300mg/day), increase of total bile acids concentration, improvement of reduced percentage of the total lipid in the micellar phase, and decrease of fecal fat excretion were demonstrated. The UDCA percentage was increased to 22.4% of total conjugated bile acids and cholic acid/chenodeoxycholic acid ratio was decreased after UDCA administration. These results showed that UDCA administrated was absorbed through intestinal mucosa and changed into the conjugated form in the liver and involved in the micellar solubilization of lipid.
財団法人日本消化器病学会の論文