A study of lymphocyte subset distribution and HLA-DR antigen expression in peripheral blood and in mucosa of the stomach, small intestine and colon.

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We have elucidated the distribution of lymphocyte subsets and the expression of HLA-DR antigen in normal peripheral blood and in normal gastrointestinal mucosa. In comparing the results from peripheral blood with those in gastrointestinal mucosa, we found significant differences. Our investigation of peripheral blood produced the following results: a 1.4 leu 3/2 ratio, 10% B cell (leu 4-DR+) and 5% DR-positive T cell. In contrast, the leu 3/2 ratio in gastric and intestinal lamin propria lymphocytes (LPL) were 1.2 and 2.0, respectively. B cells (leu 14+) were rarely detected in intraepithelial lymphocytes (TEL) and LPL of the gastrointestinal mucosa. No DR-positive TEL was seen in the gastrointestinal mucosa.Among the stomach, small intestine and colon, the small intestine had the highest value of leu 4+ TEL, leu 2+ TEL, leu 4+ LPL and leu 3+ LPL. Moreover, the small intestinal epithelium specifically exressed HLA-DR antigen in all cases.The present results suggest that the small intestine might have higher"immunoactive potentiality"than the stomach and the colon. Consequently, this higher"immunoactive potentiality"of the small intestine might be related to the lower frequency of malignant tumors in the small intestine.
財団法人日本消化器病学会の論文