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The purpose of this study is to compare oral bile acid tolerance test with vitamin B12 absorption test in order to evaluate the significance as the test to examine the absorptive capacity of ileum. Vitamin B12 absorption test has been used to determine the functional integrity of the ileum. As bile acid is also mainly absorbed from the ileum, it is presumed that change of serum bile acid after its oral administration reflects absorptive capacity of the ileum if liver function is not impaired. Upon this assumption, the change of the total serum bile acid was determined after 300 mg ursodeoxycholic acid oral administration. Bile acid was measured by enzyme-fluorometric method. Vitamin B12 absorption test was consecutively performed. Value was represented as ratio of urinary 57Co excretion to its oral dose. The subjects selected were five normal volunteers, 6 cases of gastroduodenal ulcer, 5 cases of ulcerative colitis and 4 cases of diffuse ileal disease. Following results were obtained; 1) The elevation of serum bile acid reached to the peak at 30 or 45 min after oral administration of 300 mg ursodeoxycholic acid in normal volunteers, cases of both gastro-duodenal ulcer and ulcerative colitis. While, there were no marked elevation of the serum bile acid in cases with diffuse ileal disease. 2) In vitamin B12 absorption test, urinary excretion of administered 57Co-V. B12 was less remarkable in cases with diffuse ileal disease than in cases with other gastrointestinal disease. 3) Correlation between bile acid tolerance test and vitamin B12 absorption test was demonstrated (r=0.64, Y=1.4+6.4, p<0.05).Therefore, it was concluded that bile acid tolerance test is available as the test for examining the absorptive capacity of the ileum.

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