A case of acute carbon tetrachloride poisoning.

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A 55-year-old man who had drunk for past twenty-five years accidentally ingested carbon tetrachloride. He was admitted to a local hospital, complaining of abdominal pain, nausea, vomiting and diarrhea 2 hours after ingestion. He was transferred to our hospital because his condition rapidly deteriorated. Examination on admission revealed mild jaundice and hepatomegaly. Laboratory findings were as follows; AST 5160 IU/l, ALT 3000 IU/l, T. Bil 2.5 mg/dl, PT 35.3%, superoxide dismutase (SOD) 36.2%. Haptoglobin and lipoperoxide were within normal limit. His liver function was normalized at twenty-eight days after admission. Histological findings were as follows; perivenular and pericellular fibrosis, balooned hepatocytes, infiltration of small round inflammatory cells and polymorphonuclear cells, fat droplets and necrosis of hepatocytes. These changes were dominant in centrilobular area (Zone 3). These findings were compatible to those of acute carbon tetrachloride poisoning superimposed on chronic alcoholic changes and may suggest that hepatotoxicity of carbon tetrachlo-ride is reinforced by alcohol intake.