Relationship between serum HBeAg/anti-HBe and liver histologic finding or intrahepatic HBcAg in chronic type B hepatitis.

概要

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Relationship between serum HBeAg/anti-HBe and liver histological finding or intrahepatic HBcAg was evaluated in 51 cases of chronic type B hepatitis. Including 19 cases in whom liver biopsies were performed more than 2 times, the following results were obtained.1) Liver histological finding was improved in 66.6% of 12 cases which turned to HBeAg negative, 83.3% of 6 cases which seroconveted to anti-HBe positive from HBeAg positive, while only 14.3% of 7 cases which remained to be HBeAg positive. 2) HBcAg in the nuclei and cytoplasm in liver cells was significantly decreased in cases which turned to HBeAg negative or seroconverted to anti-HBe positive. 3) Cytoplasmic HBcAg was demonstrated in the high incidence in cases with marked intralobular degeneration or necrosis in the liver. From these results, it was strongly suggested that decrease of intrahepatic HBV and also improvement of liver histological finding have occurred in cases which turned to HBeAg-negative, especially in cases which seroconverted to anti-HBe positive from HBeAg positive after treatments.
財団法人日本消化器病学会の論文