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We have established an experimental model of chronic gastric ulcer, in which the rats were operated to produce regurgitation of entire duodenal juice into the stomach by transecting the lower horizontal division of the duodenum and anastomosing the forestomach to upper part of jejunum.After 12 weeks, all 8 rats so treated have developed an ulcer with average diameter of 6mm and range from 2 to 10mm in the pre-pyloric region on the lesser curvature of the glandular stomach.Histological studies revealed chronic peptic ulcers quite similar in many respects to human gastric ulcer.As a control series, transection at the pylorus instead of the lower horizontal division of the duodenum failed to develop an ulcer.Although a considerable number of literatures have appeared regarding the experimental production of chronic gastric ulcer, most of them have applied of chemical drugs or mechanical injuries on the gastric mucosa.Our present model, on the other hand, applied chronic regurgitation of duodenal juice as a more natural phenomenon, and obtained highly uniform result of ulcer formation. Further studies using this model are warranted on pathogenesis and mechanism of chronic peptic ulceration.
財団法人日本消化器病学会の論文