Evaluation of biliary function at the time of pancreozymin-secretin test

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P-S test (pancreozymin-secretin test) has been widely employed in order to evaluate the exocrine function of the pancreas. In addition, this test also has been used for the detection of biliary disorders. In the present paper, we discuss the evaluation of P-S test as a diagnostic significance of the diseases of the biliary tract. During these 4 years we have performed 1200 cases of P-S test. We dealt with recent successive 300 cases in this study, including 16 cases of normal group, 30 cases of gallstone and cholecystitis, 8 cases of carcinoma of the gallbladder and bile ducts, 12 cases of carcinoma of the pancreas and the duodenal papilla, 18 cases of cholecystectomized patient, 16 cases of hepatitis and cirrhosis, 12 cases of colitis, 15 cases of gastro-duodenal ulcer, 19 cases of chronic pancreatitis, and others. In the normal group, the mean of the icteric index and its standard deviation were calculated in the fractions following the injection of pancreozymin and secretin.From these data we draw the range of normal values as the diagnostic chart. In the normal cases, the concentration of bile reaches its peak following ten minute fraction after the injection of pancreozymin, and the bile abruptly disappears in the duodenal contents after the stimulation by secretin. On this diagnostic chart, 63 cases (93%) of organic disorders of the biliary tract were scaled out from the normal range at least in a part.In patients who have organic disorders of biliary tract, concentrated bile following the injection of pancreozymin was not observed and bile concentration of the serial specimens from duodenal contents was higher than normal cases after injection of secretin.The possibility of both false-negative and false-positive were about 6%.
財団法人日本消化器病学会の論文

Evaluation of biliary function at the time of pancreozymin-secretin test

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