Excretion of Antibiotics into Human Bile Juice in Patients with Obstructive Jaundice

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The purpose of this paper is to discuss the factors which influence the excretion of antibioticsinto the bile juice in the cases with obstructive jaundice. The levels of antibioticssuch as Ampicillin, Carbenicillin, Thiamphenicol, Cephalothin were studied in serum andbile on complete biliary obstruction, incomplete obstruction and after biliary drainagegroup.The results are follows; the rate of biliary excretion of antibiotics in the cases ofobstructive jaundice was affected chiefly by the grade of biliary passage regardless of theamount or sort of antibiotics.In patients with complete bile duct obstruction, Ampicillin, Carbenicillin, Thiamphenicol, Cephalothin were not excreted. And in patients with incomplete bile duct obstruction, excretionof those antibiotics were a little better. However, in patient whose bile duct wasdrained, the excretion of antibiotics was encreted promptly into the bile juice and its concentrationwas moderately.These phenomena were not correlated directly with the degree or duration of jaundice andthe grade of liver damage.
財団法人日本消化器病学会の論文