INVESTIGATION OF THE GENETICS IN ALLERGIC RHINITIS. THE 3RD REPORT:HLA CLASS I AND II SPECIFICITIES OF JAPANESE CEDAR POLLINOSIS

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Thirty six patients with Japanese cedar (J.C.) pollinosis and 66 normal controls were investigated for clarifing the specificities of HLA class I (A, B, C, ) and II (DR, DQW, DRW) antigens. The patients consisted of 20 patients allergic to J.C. alone and 16 patients allergic to J.C. and other antigens such as housedust mite and/or orchard grass simultaneously. The diagnosis of the disease was made by clinical symptoms, skin test and nasal provocation test with J.C. and serum IgE antibody titer to J.C. All of the patients were positive to all of these tests, and all of the controls were negative to the tests. The results were as follows. 1. The incidence of HLA-DQW3 was more higher in the 36 patients than that in the 66 controls. (Patients: 86.1%, Controls: 65.2%, P<0.05, Pc<0.1) 2. The incidence of HLA-A26 was more higher in 20 patients allergic to J.C. alone than that in the 66 controls. (Patients: 45%, Controls: 16.7%, P<0.01, Pc<0.05) 3. The incidence of HLA DQW3 was more higher in the 16 patients allergic to multiple antigens contained J.C. than that in the 66 controls. (Patients: 93.8%, Controls: 65.2%, P<0.05, Pc<0.1) 4. In the patients group, all of the individuals who had HLA-A26 had HLA-DQW3. From the results obtained, it is considered that there may be a linkage disequilibrium relationship between HLA-A26 and HLA DQW3 in the patients. And it is suggested that the genes concerning with J.C. pollinosis may be located the locus of HLA-DQW3 or close to it.
社団法人日本耳鼻咽喉科学会の論文

INVESTIGATION OF THE GENETICS IN ALLERGIC RHINITIS. THE 3RD REPORT:HLA CLASS I AND II SPECIFICITIES OF JAPANESE CEDAR POLLINOSIS

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