Resumption of Cyclicity in Light Induced Persistent Estrus by Treatments with Serotonin or its Precursor
スポンサーリンク
概要
- 論文の詳細を見る
Female Wistar rats in persistent estrus under continuous illumination (LL) restored reproductive cyclicity after being treated with sub gonad-inhibiting doses of serotonin (5-HT) or its immediate precursor 5-hydroxytryptophan (5-HTP). Intraocular injection of 5-HTP (10μg) or 5-HT creatinine sulfate (18μg) was significantly effective. Both subcutaneous dose (100μg) and single intraperitoneal dose (1.0mg/rat) of 5-HTP effectively induced diestrous smear and ovulation, with 2 to 5 days of latency, in approximately 50% of treated rats whether they had been pinealectomized or not. Among control treatments other than changing the photoperiod form LL to alternating light and dark, ether anesthesia alone interrupted the persistent estrus in nearly 50% of the “light estrous rat” of unselected stock colony. Possible mechanism underlaying restorment of estrous cycle from “light estrus” by indole amines was discussed.
- 社団法人 日本内分泌学会の論文
著者
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SUZUKI YOSHISUKE
Department of Veterinary Physiology, Faculty of Agriculture, University of Tokyo
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Takahashi Michio
Department Of Civil Engineering College Of Engineering Nihon University
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HOMMA KAZUTAKA
Department of Veterinary Physiology, Faculty of Agriculture, University of Tokyo
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HOMMA KAZUTAKA
Department of Veterinary Physiology, Faculty of Agriculture University of Tokyo
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SUZUKI YOSHISUKE
Department of Veterinary Physiology, Faculty of Agriculture University of Tokyo
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TAKAHASHI MICHIO
Department of Veterinary Physiology, Faculty of Agriculture, University of Tokyo
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