Activin A and Superoxide Dismutase Synergistically Enhance Development of 1-Cell Mouse Embryos to the Blastocyst Stage <I>In Vitro</I>
スポンサーリンク
概要
- 論文の詳細を見る
Supplementing Whittens medium with both activin A and superoxide dismutase (SOD), either of which singly has a beneficial effect, can enhance synergistically the development of 1-cell mouse embryos to the blastocyst stage <I>in vitro</I>. To release the 2-cell block and support embryonic development up to blastocysts, the lowest concentrations were 1.0 ng/ml and 2.5 ng/ml of activin A in CD-1 and DBA/2NJcl mice, respectively, and 300IU/ml of SOD in both strains. The percent-age of cultured embryos developing from the pronuclear stage to the 3-or 4-cell stage was signifi-cantly higher in media containing both supplements at the concentrations mentioned above than in media supplemented with either activin A or SOD. Pronuclear embryos developed to either moru-lae or blastocysts in the activin A plus SOD group at significantly higher proportions (p<0.01) than those in groups treated with activin A or SOD separately. The synergism between the 2 supple-ments for releasing 2-cell block indicates that the modes of action are different for activin A and SOD.
- 日本繁殖生物学会の論文
著者
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Lu Rong
Department Of Industrial Chemistry School Of Science And Technology Meiji University
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Takahashi Michio
Department Of Internal Medicine Kitasato University School Of Medicine
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IKEDA Akihiko
Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo
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Takahashi Michio
Department Of Civil Engineering College Of Engineering Nihon University
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Ikeda Akihiko
Department Of Respiratory Medicine Nishi-kobe Medical Center
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Lu Rong
Department Of Chemistry Renmin University Of China
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Ikeda Akihiko
Department Of Cardiovascular Surgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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LU Rong
Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo
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