Light Activation of Gonadal Function Restrained by Continuous Dark Treatment in Male Rats
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概要
- 論文の詳細を見る
The confinement of male rats in complete dankness from birth until 47 days of age resulted in severe retardation of reproductive function. The supply of light-on condition for the last one week caused a remarkable overshoot of testosterone secretion beyond the level of intact animals, associating with a significant weight increase in accessory reproductive organs. Eye-enucleation nullified these effects. This androgen overshoot was considered to be occurred as a result of the removal of inhibitory effect of dark condition rather than a result of positive stimulatory effect of light-on condition.<BR>The possibility to simulate the inhibitory effect of dark condition was examined. The intra-ocular injection of a serotonin precursor (5-hydroxytryptophan) at the initiation of 7 days of light-on treatment, lowered both androgen titer and weight of accessory reproductive organs to the light-off level. This might suggest a possible role of serotonin as an inhibitory dark substance involved in neuroendocrine mechanisms.
- 社団法人 日本内分泌学会の論文
著者
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SUZUKI YOSHISUKE
Department of Veterinary Physiology, Faculty of Agriculture, University of Tokyo
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Takahashi Michio
Department Of Civil Engineering College Of Engineering Nihon University
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CHOI KYU-SIK
Department of Veterinary Physiology, Faculty of Agriculture, University of Tokyo
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