Effects of Clomiphene Citrate and Progesterone on Resting and Proliferative Cell-Populations in Mouse Uterine Epithelium
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概要
- 論文の詳細を見る
Resting cells (G<SUB>0</SUB> cells) of the uterine surface epithelium in castrated mice began to synthesize DNA with high synchrony from 10hr after the injection of 50ng of estradiol-17β with or without 5.5μg of clomiphene citrate. Highly synchronized DNA synthesis in G<SUB>0</SUB> cells elicited with estradiol was delayed approximately 5hr when the simultaneous administration of 0.5mg of progesterone was given. In Go cells of castrated mice which received 5.5μg of clomiphene or 55μg of clomiphene plus 50 ng of estradiol, DNA synthesis with partial synchrony began 15hr after the injection. The effects of estradiol were completely suppressed by the administration of 55μg of clomiphene. It is suggested that the inhibitory action of clomiphene may be due to the competitive blocking of estrogen binding, while progesterone suppresses the estrogen-induced DNA synthesis of the surface epithelium and transfers them to the G<SUB>0</SUB> cell-compartment.
- 社団法人 日本内分泌学会の論文
著者
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OKADA Hiroji
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
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Kimura Junji
Department Of Chemistry And Biological Science College Of Science And Engineering Aoyama Gakuin Univ
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Okada Hiroji
Department Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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OBATA TADASHI
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
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