STEROID RECEPTORS IN UTERINE CERVICAL CANCERS
スポンサーリンク
概要
- 論文の詳細を見る
In cervical cancers, the estrogen receptor (ER) and progestin receptor (PR) were characterized in the cytosol protein. Receptor levels were determined in cytosol, nuclear KCI extract, and nuclear KCl unextractable fraction in various cervical cancer tissues.The androgen receptor (AR) was also similarly characterized. In the cytosol, the estrogen (E_2)-ER complex and the promegesterone (R5020)-PR complex were sedimented at approximately the 5S and 8S or the 4S and 8S regions, respectively, by 5-20% Iinear sucrose gradient centrifugation.A steroid specificity study showed the presence of an estrogen-specific and a progestin-specific binder. The dissociation constant of the specific binder for estrogen (ER), progestin (PR), or androgen (AR) was approximately 10^<-10> to 10^<-9>M in cytosol, nuclear KC1, and nuclear KCl unextractable fraction in detected cases. Levels were determined by Scatchard analyses, using the dextran-coated charcoal (DCC) adsorption method for the former two and the washing method for the latter one.ER, PR, or AR was detected in some cases of determined cervical cancers (27 cases of squamous cell carcinoma, and 7 cases of adenocarcinoma) ; regardless of the histological types, ER was detected in almost all cases. PR was not detected in the given cases of cervical adenocarcinoma. It is suggested that estrogen stimulation of PR synthesis in cervical adenocarcinoma may be damaged.
- 社団法人日本産科婦人科学会の論文
- 1986-04-01
著者
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TAMAYA Teruhiko
Department of Obstetrics and Gynecology, Gifu University School of Medicine
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FUJIMOTO Jiro
Department of Obstetrics & Gynecology, Gifu University School of Medicine
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Sato Shohei
Department Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Sato Shohei
Department Of Chemistry College Of Science And Engineering Aoyama Gakuin University
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WATANABE YOSHINOBU
Department of Orthopaedic Surgery, Teikyo University
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OKADA Hiroji
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
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Okada H
Kyoto Prefectural Univ. Medicine Kyoto Jpn
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Okada Hiroji
Department Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Fujimoto Jiro
Departmen T Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Tamaya T
Department Of Obstetrics And Gynecology Gifu University School Of Medicine
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Tamaya Teruhiko
Departmen T Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Tamaya T
Departmen T Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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ARAHORI Kenji
Departmen t of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
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Arahori Kenji
Departmen T Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Okada Hiroji
Dept. Of Obstet & Gynecol. Kyoto Prefectural Univ. Med.
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Watanabe Y
Nihon Univ. Tokyo Jpn
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Watanabe Yoshinobu
Department Of Orthopaedic Surgery Kyoto Prefectural University Of Medicine
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WATANABE Yoshinobu
Departmen t of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
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