CELLULAR EXISTENCE OF ESTROGEN RECEPTOR IN C_3H MOUSE MAMMARY TUMOR
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概要
- 論文の詳細を見る
Estrogen receptor (ER) in the C_3H mouse mammary tumor was characterized in the cytosol and determined in the nuclear KCI extract and the nuclear KCI unextractable fraction (non-extract).In the cytosol, the extradiol (E_2)-ER complex was sedimented in the 8S region by 5-20% linear sucrose gradient centrifugation. A steroid specificity study showed the presence of estrogen-specific binder with a dissociation constant (Kd) of approximately 2nM.ER levels ih the cytosol, the nuclear KCI extract, and the suspension of nuclear KCI unextractable fraction were determined by Scatchard analyses, using the dextran-coated charcoal (DCC) ,adsorption method for the former two and the sedimentation method for the latter.Although ER was present in the nuclear fractions, it seems more plausible that cytosol ER contributes to nuclear translocation of the estrogen-ER complex.The results suggest the presence of an intranuclear mechanism for the estrogen action.
- 社団法人日本産科婦人科学会の論文
- 1986-05-01
著者
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TAMAYA Teruhiko
Department of Obstetrics and Gynecology, Gifu University School of Medicine
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FUJIMOTO Jiro
Department of Obstetrics & Gynecology, Gifu University School of Medicine
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WATANABE YOSHINOBU
Department of Orthopaedic Surgery, Teikyo University
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OKADA Hiroji
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
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Okada H
Kyoto Prefectural Univ. Medicine Kyoto Jpn
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Okada Hiroji
Department Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Fujimoto Jiro
Departmen T Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Tamaya T
Department Of Obstetrics And Gynecology Gifu University School Of Medicine
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Tamaya Teruhiko
Departmen T Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Tamaya T
Departmen T Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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ARAHORI Kenji
Departmen t of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
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Arahori Kenji
Departmen T Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Okada Hiroji
Dept. Of Obstet & Gynecol. Kyoto Prefectural Univ. Med.
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Watanabe Y
Nihon Univ. Tokyo Jpn
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Watanabe Yoshinobu
Department Of Orthopaedic Surgery Kyoto Prefectural University Of Medicine
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WATANABE Yoshinobu
Departmen t of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
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