Studies on Nucleosides and Nucleotides. II. Selective Acylation of 5'-Hydroxyl Group of Thymidine
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概要
- 論文の詳細を見る
Treatment of thymidine and either acetic acid or benzoic acid with diethyl azodicarboxylate (<B>1</B>) and triphenyl-phosphine (<B>2</B>) in dioxane afforded 5′-<I>O</I>-acetyl or 5′-<I>O</I>-benzoyIthymidine along with a trace of 3′,5′-di-<I>O</I>-acylated product. When thymidine and benzoic acid or <I>p</I>-substituted benzoic acids were allowed to react with <B>1</B> and <B>2</B> in hexamethylphosphoric triamide(HMPA), the corresponding 5′-<I>O</I>-aroylthyinidines were selectively obtained. The aroyl groups having electron-withdrawing substituents were much more readily removed than those having electronreleasing groups under mild alkaline conditions.
- 公益社団法人 日本化学会の論文
著者
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Kimura Junji
Department Of Chemistry And Biological Science College Of Science And Engineering Aoyama Gakuin Univ
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Mitsunobu Oyo
Department Of Chemistry College Of Science And Engineering Aoyama Gakuin University
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Fujisawa Yoshiyuki
Department of Chemistry, College of Science and Engineering, Aoyama Gakuin University
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