ニトロフラン誘導体の食品防腐剤としての研究-XVI. : フリルフラマイド接触系における芽胞懸濁液の吸光度変化

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The effects of furylfuramide (FF) on the germination and successive outgrowth of two bacterial spores were investigated by measuring the change in optical density of spore suspensions under several exposing systems to FF, in order to substantiate the microscopic observations which suggested that this drug acted to inhibit the outgrowth not at germination, but during the stage from “swelling” to “emergence” in the developmental process of the bacterial spore. The results obtained were summarized as follows: 1. FF did not inhibit the germination in physiological germinant solution even at ten times more than MIC for both microbes, although in PGY medium the time required to reach minimum optical density was prolonged in proportion to the concentration of FF in the case of B. coagulans. 2. When the dormant spores were exposed to FF in phosphate buffer, it had no effectiveness on either germination or outgrowth, but when the microbes were exposed in physiological germinant, the effect of FF was shown as the prolongation of the lag phase of the outgrowth in the medium without FF.
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