脂質の榮養價に関する研究-XII : 高度不飽和酸の榮養價及び毒性について(3)

概要

論文の詳細を見る
In the previous paper* we have established that the genuine highly unsaturated fatty acids show nutritive effects upon the growth of rats, and that long-believed toxicity of highly unsaturated acids is not produced by the acids themselves but actually by formation of autoxidized matters. Moreover, it has been observed that the autoxidized liquid acids of linseed oil cause the same toxicity to the rats, and the toxic effect which is produced by peroxide structure under influence of atmospherio oxygen. When the peroxide was liberated from the autoxidized acids by potassium iodide, the acids became “not-toxic”. From these results we assumed that the peroxide liberated products of autoxidized highly unsaturated acids might become as not-toxic as in case of liquid acids of linseed oil. In order to prove this assumption, the authors liberated the peroxide of autoxidized highly unsaturated acids by Leas peroxide-determination method as reported previously. In consequence, just as we had expected, peroxide liberated highly unsaturated acids became “not-toxic”, and showed nutritive effects upon the growth of rats (Tables 1-2). Other details obtained from the present assay may be summarized like this. (1) As shown in Table 3, the lethal dose of peroxide to mice is 278 mg. total peroxide oxygen per Kg. (LD50). (2) The peroxide was found from liver and meat oil of rats when the autoxidized unsaturated acids were fed, and if the fed fat contained many quantity of peroxide, the peroxide value would became higher than that of control oils (Table 4). (3) The number of mitochondria separated from rats liver is decreased when autoxidized fatty acids are added to the mitochondria solution in uitro (Fig. 1). On the basis of these findings, it was concluded that the toxicity of peroxide contained in autoxidized unsaturated fatty acids was produced in the result of injuring the tissues of rats or by destruction of the enzymes in their bodies.
公益社団法人日本水産学会の論文

脂質の榮養價に関する研究-XII : 高度不飽和酸の榮養價及び毒性について(3)

スポンサーリンク

概要

著者

関連論文

スポンサーリンク