水産物のシロネズミコレステロール代謝におよぼす影響-III : オオバモク脂質の効果

概要

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In a previous work ?? the authors observed that fucosterol isolated from brown algae could slightly reduce liver cholestrol in rats but almost no effect against their plasma cholesterol. In 1962 Reiner and his co-workers reported that fucosterol caused a significant diminution in plasma cholesterol level of young Leghorn cockerels. Using rats, the authors re-examined the effect of fucosterol on cholesterol metabolism. In this experiment, check was also made for the effects of unsaponifiable fraction and of methyl ester of fatty acids isolated from Sargassum ringoldianum. Rats were fed ad lib. for 16 days a diet containing fucosterol, fucosterol-free unsaponifiable matter of Sargassum lipids or methyl ester of the fatty acids separated from the same algae. Exogenous (1%) cholesterol was added to each group of the diet. As shown in Table 3, fucosterol and other unsaponifiable matter could reduce slightly plasma and liver cholesterol. However, the effect of these substances was lower than β-sitosterol used as control. Methyl ester of fatty acids showed no effect. The differences of the effects between the present results and Reiners are probably originated from the difference of animals used for the tests.