水産物のシロネズミコレステロール代謝におよぼす影響に関する研究-2-

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In a previous work1) the cuttlefish liver oil proved effective to reduce plasma cholesterol of rats. Problems arising from the study are if each of the two major highly unsaturated fatty acids of the oil, eicosapentaenoic and docosahexaenoic acids, is as effective as the other for cholesterol metabolism, and if these fatty acids follow the same reduction mechanism as that of linoleic acid. To examine these points rats were fed ad lib. for 12 weeks with either a fat-free diet, a diet containing 50 mg methyl eicosapentaenoate or the same amount of methyl docosahexaenoate separated from cuttlefish liver oil, with or without (1%) cholesterol. The results indicated that eicosapentaenoic acid could reduce plasma cholesterol more than docosahexaenoic acid. The reduction mechanism of each of these fatty acids, however, looks different from that of linoleic acid.
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