水産物のシロネズミコレステロール代謝におよぼす影響に関する研究-IV : アサクサノリ中の有効成分の分別 (1)

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In a previous papert the authors showed that the inclusion of dried purple laver (Porphyra tenera) in the diets of rats reduced the level of plasma cholesterol. This paper describes attempts to define the activity in terms of solubility. As shown in Fig. 1 purple laver was extracted with ether, several percentages of ethanol and distilled water. Donryu strain rats were fed ad libitum for 16 days with diets containing the fractions obtained. The ether-soluble fraction at the level of only 0.016% in the basal diet was the most effective for reducing plasma cholesterol. The 50 per cent ethanol- and water soluble frac-tions were also effective, but the absolute- and 75 per cent ethanol-soluble fractions increased the plasma cholesterol of rats. The residue after extraction had a cholesterol-depressing effect, possibly because some water-soluble material still remained (Table 3). This Bulletin: 29, 1020-23 (1963).