A New Diapause Hormone Molecule of the Silkworm, Bombyx mori
スポンサーリンク
概要
- 論文の詳細を見る
Embryonic diapause of the silkworm, Bombyx mori, is induced by a neuropeptide, diapause hormone (DH), which is secreted from suboesophageal ganglion (SG). cDNA clones for diapause hormone were isolated from a cDNA library constructed from poly A+ RNA of SG. Sequencing from 5-end to 272 by revealed that the cDNA encodes the DH sequence which is identical to the previously isolated natural peptide except for one amino acid. The 19th amino acid of the DH deduced from the cDNA was Trp instead of Cys in the sequence of the peptide isolated previously (Bom DH-I [19-Cys]). This sequence was found in the DH preparation recently isolated from SGs of day 2 to 3 pupae of B. mori. A synthetic peptide amide with Trp at 19 exhibited biological activity comparable to the peptide amide with Cys at 19. Thus, the amidated 24 amino acid peptide with Trp at 19 is concluded to be a new diapause hormone molecule and named BomDH-I [19-Trp].
著者
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Yamashita Okitsugu
Laboratory Of Sericultural Science
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Imai Kunio
Laboratory Of Bioorganic Chemistry Graduate School Of Bioresources Mie University
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Shin Masaru
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Ikeda Motoko
Laboratory Of Sericulture And Entomoresources Graduate School Of Bioagricultural Sciences Nagoya Uni
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Isobe Minoru
Laboratory Of Organic Chemistry Bioagricultural Sciences Nagoya University
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NAKAZAWA Yoshitaka
Laboratory of Chemurgy, Faculty of Bioresources, Mie University
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SATO Yukihiro
Radioisotope Research Center, Nagoya University
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MENJO Nobuo
Laboratory of Chemurgy, Faculty of Bioresources, Mie University
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KOMIYA Takashi
Laboratory of Chemurgy, Faculty of Bioresources, Mie University
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SAITO Hiroyuki
Abrahi Laboratories, Shionogi and Co., Ltd.
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SAKAKIBARA Kiyoshi
Laboratory of Sericultural Science, School of Agriculture, Nagoya University
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YAMASHITA Okitsugu
Laboratory of Sericultural Science, School of Agriculture, Nagoya University
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IKEDA Motoko
Laboratory of Sericultural Science, School of Agriculture, Nagoya University
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SHIN Masaru
Shionogi Laboratories, Shionogi and Co., Ltd.
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