Synthesis of corticotropin peptides. XIII. The synthesis of a hexacosapeptide and a heptacosapeptide corresponding to the first twenty-six and twenty-seven amino acid residues of corticotropin (ACTH).
スポンサーリンク
概要
- 論文の詳細を見る
The syntheses are described of a hexacosapeptide H–Ser–Tyr–Ser–Met–Glu–His–Phe–Arg–Trp–Gly–Lys–Pro–Val–Gly–Lys–Lys–Arg–Arg–Pro–Val–Lys–Val–Tyr–Pro–Asn–Gly–OH (I) and a heptacosapeptide H–Ser–Tyr–Ser–Met–Glu–His–Phe–Arg–Trp–Gly–Lys–Pro–Val–Gly–Lys–Lys–Arg–Arg–Pro–Val–Lys–Val–Tyr–Pro–Asn–Gly–Ala–OH (II) corresponding to the first twenty-six and twenty-seven amino acid residues, respectively, of corticotropin (ACTH), in which a new protecting group 1-methylcyclohexyloxycarbonyl (Mhoc) is utilized for the temporary protection of the ε-amino function of lysines. The <I>in vivo</I> steroidogenic potencies of the synthetic peptides I and II are compared on a molar basis with those of ACTH(1–18)-NH<SUB>2</SUB> and synthetic human ACTH (α<SUB>h</SUB>-ACTH) to demonstrate that the relative potencies of I and II <I>vs.</I> ACTH(1–18)–NH<SUB>2</SUB> are 2.3 and 2.3–3.8, respectively, and those <I>vs.</I> α<SUB>h</SUB>-ACTH are 1.1 and 1.1–1.8, respectively.
- 公益社団法人 日本化学会の論文
著者
-
Shin Masaru
Shionogi Research Laboratories Shionogi & Co. Ltd.
-
Inouye Ken
Shionogi Research Laboratories, Shionogi & Co., Ltd.
-
Sumitomo Yoshie
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
SHIN Masaru
Shionogi Laboratories, Shionogi and Co., Ltd.
関連論文
- Expression and Characterization of Rat Pancreatic Secretory Trypsin Inhibitor-I and -II in Saccharomyces cerevisiae, and Simple Purification by Affinity Chromatography
- A New Diapause Hormone Molecule of the Silkworm, Bombyx mori
- Synthesis of corticotropin peptides. X. The synthesis of ACTH(1-18)-OH, ACTH(1-18)-NH2 and ACTH(1-19)-NH2.
- Synthetic studies on quinoxaline antibiotics. III. Synthesis of nortriostin A, a triostin A analog lacking N-methyl groups on the cystine and valine residues.
- Synthetic studies on quinoxaline antibiotics. II. Synthesis of triostin A.
- Synthesis of corticotropin peptides. XIV. The synthesis of two octadecapeptides corresponding to the amino acid sequence 22-39 of porcine and human corticotropins.
- Synthesis of corticotropin peptides. XIII. The synthesis of a hexacosapeptide and a heptacosapeptide corresponding to the first twenty-six and twenty-seven amino acid residues of corticotropin (ACTH).
- Synthesis of corticotropin peptides. XVI. The total syntheses of porcine and human corticotropins.
- Synthesis of TACK, a New Chloromethyl Ketone Derivative of Arginine
- Synthetic studies on quinoxaline antibiotics. Synthesis of quinoxaline-2-carbonyl tetradepsipeptide derivatives related to triostin A.
- Synthesis of corticotropin peptides. XV. The synthesis of an undecapeptide and a nonapeptide derivatives related to the amino acid sequence 11-21 of corticotropin.
- A synthesis of human proinsulin C-peptide.