Synthesis of corticotropin peptides. XVI. The total syntheses of porcine and human corticotropins.
スポンサーリンク
概要
- 論文の詳細を見る
The syntheses are described of two nonatriacontapeptides corresponding to the primary structure of porcine corticotropin (α<SUB>p</SUB>-ACTH) and that of human hormone (α<SUB>h</SUB>-ACTH). The porcine peptide is synthesized by assembling three fragment peptides corresponding to ACTH(1–10), ACTH(11–21) and α<SUB>p</SUB>-ACTH (22–39). The Synthetic product is compared with natural α<SUB>p</SUB>-ACTH in terms of chemical, physicochemical, and biological properties to establish their identity. The human peptide is synthesized <I>via</I> two different routes, one of which is the same as that employed for the synthesis of porcine peptide. The two synthetic preparations of human peptide are not only indistinguishable from each other, but also very similar to α<SUB>p</SUB>-ACTH in various items of physicochemical measurements and in the <I>in vivo</I> steroidogenesis assay. The collected data prove the satisfactory synthesis of α<SUB>h</SUB>-ACTH as well as α<SUB>p</SUB>-ACTH.
- 公益社団法人 日本化学会の論文
著者
-
Inouye Ken
Shionogi Research Laboratories, Shionogi & Co., Ltd.
-
Otsuka Hideo
Shionogi Research Laboratories, Shionogi & Co., Ltd.
-
Otsuka Hideo
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
Watanabe Kunio
Shionogi Research Laboratory, Shionogi & Co., Ltd.
関連論文
- Synthesis of corticotropin peptides. X. The synthesis of ACTH(1-18)-OH, ACTH(1-18)-NH2 and ACTH(1-19)-NH2.
- Synthetic studies on quinoxaline antibiotics. III. Synthesis of nortriostin A, a triostin A analog lacking N-methyl groups on the cystine and valine residues.
- Synthetic studies on quinoxaline antibiotics. II. Synthesis of triostin A.
- Synthesis of corticotropin peptides. XIV. The synthesis of two octadecapeptides corresponding to the amino acid sequence 22-39 of porcine and human corticotropins.
- Synthesis of corticotropin peptides. XIII. The synthesis of a hexacosapeptide and a heptacosapeptide corresponding to the first twenty-six and twenty-seven amino acid residues of corticotropin (ACTH).
- Synthesis of corticotropin peptides. XVI. The total syntheses of porcine and human corticotropins.
- Synthesis of TACK, a New Chloromethyl Ketone Derivative of Arginine
- Synthetic studies on quinoxaline antibiotics. Synthesis of quinoxaline-2-carbonyl tetradepsipeptide derivatives related to triostin A.
- Synthesis of corticotropin peptides. XV. The synthesis of an undecapeptide and a nonapeptide derivatives related to the amino acid sequence 11-21 of corticotropin.
- A synthesis of human proinsulin C-peptide.