Synthesis of corticotropin peptides. XIV. The synthesis of two octadecapeptides corresponding to the amino acid sequence 22-39 of porcine and human corticotropins.
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概要
- 論文の詳細を見る
The syntheses are described of two octadecapeptides, H–Val–Tyr–Pro–Asn–Gly–Ala–Glu–Asp–Glu–Leu–Ala–Glu–Ala–Phe–Pro–Leu–Glu–Phe–OH (Ip) and H–Val–Tyr–Pro–Asn–Gly–Ala–Glu–Asp–Glu–Ser–Ala–Glu–Ala–Phe–Pro–Leu–Glu–Phe–OH (Ih), corresponding to a tryptic fragment (positions 22–39) of porcine corticotropin (α<SUB>p</SUB>-ACTH) and that of human hormone (α<SUB>h</SUB>-ACTH), respectively. The porcine pep tide and the corresponding human peptide are prepared simultaneously by an identical synthetic procedure except for the introduction of amino acid residue in position 31. Synthetic peptide Ip is compared with the authentic α<SUB>p</SUB>-ACTH (22–39), which has been isolated from a tryptic hydrolysate of natural α<SUB>p</SUB>-ACTH, in terms of chemical and physicochemical properties to establish their identity. These data as well as those obtained with human peptide Ih prove the satisfactory synthesis of the two octadecapeptides.
- 公益社団法人 日本化学会の論文
著者
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Inouye Ken
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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Inouye Ken
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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Watanabe Kunio
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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Watanabe Kunio
Shionogi Research Laboratory, Shionogi & Co., Ltd.
関連論文
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