タイトル無し

概要

論文の詳細を見る
The effects of hepatic circulatory disturbance on pathogenesis of hepatic damage and dysfunction induced by endotoxin were experimentally examined, and the below results were obtained. 1) Endotoxin induced focal random coagulative necrosis following accumulation of fibrin and inflammatory cells in the sinusoids and led to marked elevation of serum transaminase levels. 2) Heparin markedly inhibited the above reaction. 3) Thrombin infusion from the portal vein induced focal random coagulative necrosis resembling the lesions induced by endotoxin, following formation of thrombus in the sinusoids, and marked elevation of serum transaminase levels. 4) Endotoxin increased portal vascular resistance, and elevated the portal vein pressure. 5) Partial obstruction of the portal vein induced reduction of portal venous blood flow, and led to the elevation of serum transaminase levels without hepatic necrosis. 6) Endotoxin infusion from the portal vein following partial obstruction of the portal vein induced focal random, zonal and massive hepatic necrosis, as well as marked elevation of serum transaminase levels.<BR>These results suggest that hepatic necrosis induced by endotoxin is attributed to circulatory disturbence of the sinusoids resulted from the formation of fibrin thrombus and reduction of portal venous blood flow, and that massive hepatic necrosis may be induced by coexistence of endotoxin and marked reduction of portal venous blood flow.
社団法人日本肝臓学会の論文

タイトル無し

スポンサーリンク

概要

著者

関連論文

スポンサーリンク