肝細胞表面へのHBs抗原表出に関する検討--HBs抗原表出の意義,殊に肝細胞障害との関連性について

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Antigenic activity of isolated live hepatocytes surface was investigated in 30 patients with various liver diseases. Employing direct immunofluorescent method, 8 out of 18 patients with HBsAg in their serum were revealed to express HBsAg on their hepatocyte surfaces. All these 8 patients, examined by frosen sectioned immunofluorescent method, possesed HBsAg or HBcAg (frequently both) in their hepatocytes, and localization of HBsAg was of cytoplaSmic pattern. Electron microscopic findings of surface HBsAg positive patients showed no significant episodes around cytoplasmic membrane. Transaminase values of surface HBsAg positive patients was significantly elevated as compared with that of negative patients.<BR>One case, followed up for long term, showed conversion to surface HBsAg negative from positive synchronizing with normalization of transaminase values.<BR>These findings discussed for the role of surface expressed HBsAg as target antigen of host' s immune attack.
社団法人日本肝臓学会の論文