CORRELATION OF TERATOGENICITY OF ASPIRIN TO THE STAGESPECIFIC DISTRIBUTION OF SALICYLIC ACID IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
A study was made of the stage-specific teratogenicity in rat fetuses from dams given different dosages of aspirin throughout and also during 3 subdivided organogenetic periods of pregnancy (days 8-10, 11-13 and 15-17 of gestation). The stage-specific teratogenicity of the drug, from the aspect of the dam-fetus distribution pattern of salicylic acid during the respective periods of pregnancy was also determined. The stage when the malformations, typical of aspirin toxicity (cranioschisis, spondyloschisis, abdominal fissure, cleft palate) were most frequent was from day 8 to day 10 of gestation. Even in this period when the fetuses were most susceptible to this teratogen, however, the drug was not teratogenic unless it was ingested for 3 or more consecutive days. There were no significant alterations in the maternal plasma levels of salicylic acid during the respective periods. During the first 8-10 days of gestation, the fetal levels of salicylic acid remained significantly high (p<0.05) at any stage of measurement during the 10 hours after application of aspirin, compared with the maternal plasma levels. Furthermore, as pregnancy progressed, the amount of salicylic acid transferred to the fetuses tended to gradually decrease, despite of the fact that the maternal plasma levels of the agent remained fairly stable. On the other hand, the placental levels of salicylic acid tended to be increasingly elevated with the pregression of pregnancy. Thus, salicylic acid is most readily transferred to the fetuses at high concentrations at days 8-10 of gestation. Also, from the finding that aspirin proved to be teratogenic when the fetuses were exposed to a given period (3 days or more), the teratogenic action of aspirin is attributed to a direct action of this compound.
- 社団法人 日本薬理学会の論文
著者
-
Nakao Kenzo
Department Of Biochemistry Kyoto Pharmaceutical University
-
Urano Tomoko
Department Of Pharmacology Hoshi College Of Pharmacy
-
HIRAMORI Tameo
Department of Pharmacology, Hoshi College of Pharmacy
-
Yanaura Saizo
Department Of Applied Pharmacology School Of Pharmacy Hoshi University
-
Tagashira Eijiro
Department Of Pharmacology Hoshi College Of Pharmacy
-
Tagashira Eijiro
Department Of Pharmacology School Of Pharmacy Hoshi University
-
Ishikawa Shigeru
Department Of Chemistry School Of Science Tokai University
-
ISHIKAWA Shigeru
Department of Pharmacology, Hoshi College of Pharmacy
関連論文
- BIOCHEMICAL ASPECTS IN THE EXPERIMENTAL BARBITAL DEPENDENCE IV : ITS EFFECT ON THE HEXOKINASE AND PHOSPHOFRUCTOKINASE ACTIVITIES IN THE RAT BRAIN
- STUDIES ON DRUG DEPENDENCE (Report 87) : Biochemical aspects of experimental barbital dependence. Effect on neural energy and gluco-metabolizing system
- BIOCHEMICAL ASPECTS OF PENTYLENETETRAZOLE INDUCED SEIZURE
- BIOCHEMICAL ASPECTS OF EXPERIMENTAL BARBITAL DEPENDENCE III : EFFECT ON NEURAL ENERGY RESERVE SYSTEM
- INHIBITORY MECHANISM OF LONG-CHAIN, UNSATURATED FATTY ACIDS ON PLATELET ACTIVATION
- ATTENUATION OF ASPIRIN ANALGESIA BY CALCIUM LOADING IN HEALTHY SUBJECTS
- BEHAVIORAL CHANGES IN MORPHINE-TOLERANT MICE
- STUDIES ON DRUG DEPENDENCE (REPT. 72) BRAIN MORPHINE LEVELS OF DEPENDENT MICE BY DAF (DRUG-ADMIXED FOOD) METHOD
- STUDIES ON DRUG DEPENDENCE (REPT. 52) INDUCTION OF MORPHINE DEPENDENT MICE BY DAF (DRUG-ADMIXED FOOD) METHOD
- A NEW SCREENING METHOD FOR EVALUATING ANTITUSSIVES IN CONSCIOUS GUINEA PIGS
- EFFECTS OF DIIOSPROPYL-1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) ON ACUTE TOXICITY OF VARIOUS DRUGS AND HEAVY METALS.
- HISTAMINE RECEPTORS IN THE BRONCHIAL MUSCULATURE AND VASCULATURE OF THE DOG
- COMPARISON OF PHARMACOLOGICAL PROPERTIES BETWEEN PENTAZOCINE AND HOMOBENZOMORPHAN DERIVATIVES
- DRUG EFFECTS ON ELECTRICAL ACTIVITIES OF THE CANINE TRACHEAL CILIATED CELLS
- DIRECT EFFECTS OF EXPECTORANTS ON THE TRACHEOBRONCHIAL SYSTEM IN VIVO
- EFFECTS OF SOME DRUGS ON THE IMMUNE RESPONSE IN THE RESPIRATORY TRACT
- STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
- The Electronic Structures of the Clean and H Adsorbed (111) Surfaces for MC (M=Ti,Zr and Nb); DV-Xα MO Calculations (第15回表面科学講演大会論文特集-2-)
- NARCOTIC PHYSICAL DEPENDENCE AND URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
- STUDIES ON DRUG DEPENDENCE (REPORT 71) : SECONDARY WITHDRAWAL SIGNS IN NITRAZEPAM-EXPERIENCED RAT OFFSPRING
- STUDIES ON DRUG DEPENDENCE (REPORT 70) : RAPID DEVELOPMENT OF PHYSICAL DEPENDENCE ON NITRAZEPAM IN RAT NEONATES
- Sex Differences in the Induction of Physical Dependence on Pentobarbital in the Rat
- A NEW APPROACH FOR ASSESSMENT OF NARCOTIC PHYSICAL DEPENDENCE USING URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
- MODE OF ANTAGONISTIC ACTION OF LEVALLORPHAN IN MORPHINE-DEPENDENT RATS AND ASSESSMENT OF PHYSICAL DEPENDENCE LIABILITY
- CHANGES IN BILE COMPOSITION DURING GALLSTONE FORMATION IN HAMSTERS
- EATING BEHAVIOR REVEALS RATS PREFERENCE FOR MORPHINE
- TOLERANCE TO AND DEPENDENCE ON BARBITURATES IN MICE WITH REFERENCE TO THE DATA IN RATS
- EFFECT OF BR-227,A NEW BROMHEXINE DERIVATIVE, ON SECRETORY ACTIVITIES OF TRACHEAL SECRETORY CELLS
- Effects of Antiallergic Drugs on Bronchial and Cutaneous Anaphylaxes in Lewis Rats
- EFFECTS OF EXPECTORANTS ON THE CANINE TRACHEAL CILIATED CELLS
- EFFECTS OF β-ADRENOCEPTOR STIMULANTS ON THE CANINE TRACHEAL CILIATED CELLS
- EFFECTS OF QUINIDINE AND CIMETIDINE ON METHAMPHETA MINE STEREOTYPY IN RATS
- CONTINUOUS DETERMINATION OF TRACHEOBRONCHIAL SECRETORY ACTIVITY IN DOGS
- STUDIES ON DRUG DEPENDENCE (REPT. 89) DEVELOPMENTAL TOXICITY OF ETHANOL ON THE OFFSPRING OF RATS
- STUDIES OF DRUG DEPENDENCE, 88TH REPORT : MORPHINE DEPENDENCE OF NITRAZEPAM-EXPERIENCED RATS
- THE ROLE OF DAF (DRUG-ADMIXED FOOD) METHOD FOR SAFETY EVALUATION OF SEDATIVE-HYPNOTIC DRUGS
- STUDIES OF PHYSICAL DEPENDENCE ON CINEPAZIDE IN RATS
- BIOCHEMICAL ASPECTS OF EXPERIMENTAL BARBITAL DEPENDENCE II: EFFECT ON GLYCOMETABOLISM
- EFFECTS OF 8-(2-FLUOROETHYL)-3α-HYDROXY-lαH, 5αH-TROPANIUMBROMIDE BENZILATE (Ba598Br) ON ALLERGY AND DRUG-INDUCED ASTHMAS
- ANALYSIS OF EFFERENT DISCHARGES OF THE PHRENIC NERVE DURING THE COUGH REFLEX
- PERIPHERAL EFFECTS OF MORPHINE AND CODEINE ON THE COUGH REFLEX
- INFLUENCE OF TRACHEAL MUSCULAR TONE ON THE INITIATION OF COUGH REFLEX
- PHYSICAL DEPENDENCE ON MORPHINE, PHENOBARBITAL AND DIAZEPAM IN RATS BY DRUG-ADMIXED FOOD INGESTION
- A NEW METHOD FOR INDUCTION OF THE COUGH REFLEX
- EXPECTORANT EFFECT OF BROMHEXINE DERIVATIVES
- HISTOLOGICAL AND HISTOCHEMICAL ANALYSIS OF EXPECTORANT EFFECT
- A ROLE OF LYSOSOMAL ENZYMES IN THE MECHANISM OF MUCOLYTIC ACTION OF BROMHEXINE
- BEHAVIOR OF MUCUS GLYCOPROTEINS OF TRACHEAL SECRETORY CELLS FOLLOWING L-CYSTEINE METHYL ESTER TREATMENT
- EFFECT OF PILOCARPINE ON BEHAVIOR OF MUCUS GLYCOPROTEINS OF CANINE TRACHEAL SECRETORY CELLS
- CLINICAL ASSESSMENT OF ANALGESICS USING ULTRASONIC STIMULATION : —A NEW METHOD—
- CROSS-CEPENDENCE BETWEEN PHENOBARBITAL AND ALCOHOL IN RATS
- EFFECTS OF SOME BILE ACIDS ON HEPATIC BLOOD FLOW IN DOGS—WITH REFERENCE TO BILIARY EXCRETION
- A NEW ANALGESIC TESTING METHOD USING ULTRASONIC STIMULATION : I. EFFECTS OF NARCOTIC AND NONNARCOTIC ANALGESICS
- NEW METHOD FOR EVALUATING BRONCHOMOTOR AND BRONCHOSECRETORY ACTIVITIES : EFFECTS OF PROSTAGLANDINS AND ANTIGEN
- CHOLERETIC PROPERTIES OF URSODEOXYCHOLIC ACID AND CHENODEOXYCHOLIC ACID IN DOGS
- PREFERENCE FOR MORPHINE AND DRUG-SEEKING BEHAVIOR IN MORPHINE DEPENDENT RATS
- EATING PATTERN OF MORPHINE DEPENDENT RATS
- ORAL SELF-ADMINISTRATION OF MORPHINE IN RATS
- TOLERANCE TO AND DEPENDENCE ON NEUROLEPTICS IN RAT NEONATES
- THE ROLE OF BRONCHOCONSTRICTION IN COUGH REFLEX
- A Molecular Orbital Study on the Aldol Reaction of Aldehyde with Silyl Ketene Acetal Catalyzed by Borane
- PROPERTY OF POTASSIUM-INDUCED CONTRACTURE OF THE GUINEA-PIG TRACHEAL MUSCLE IN RELATION TO CALCIUM
- FORMATION OF PHYSICAL DEPENDENCE ON BARBITURATES AND CEREBRAL MONOAMINES
- EFFECTS OF PROPRANOLOL ON BARBITAL DEPENDENCE FORMATION AND WITHDRAWAL SIGNS
- CROSS-PHYSICAL DEPENDENCE LIABILITY OF PSYCHOTROPIC DRUGS IN RATS DEPENDENT ON BARBITURATES
- ALTERATION OF CONVULSIVE THRESHOLD AND SENSITIVITY TO CNS ACTING DRUGS IN SEDATIVE-HYPNOTICS-EXPERIENCED RAT OFFSPRING
- PARTICIPANT OF SEROTONIN TURNOVER RATE IN THE BRAIN ON BARBITAL WITHDRAWAL CONVULSION
- BIPHASIC ACTION OF PENTAZOCINE IN MORPHINE-DEPENDENT RATS
- CORRELATION OF TERATOGENICITY OF ASPIRIN TO THE STAGESPECIFIC DISTRIBUTION OF SALICYLIC ACID IN RATS
- ENHANCEMENT OF DRUG WITHDRAWAL CONVULSION BY COMBINATIONS OF PHENOBARBITAL AND ANTIPSYCHOTIC AGENTS
- The effect of trans-4-guanidinomethylcyclohexanecarboxylic acid p-tert-butylphenyl ester hydrochloride (NCO-650) on Ascaris suum antigen-induced bronchoconstriction in dogs.
- Strain difference in an allergic asthma model in rats.
- Involvement of histamine H1- and H2-receptors in induced asthmas in dogs.
- ALLERGY INDUCED ASTHMA WITH ASCARIS SUUM ADMINISTRATION TO DOGS
- Involvement of central serotonergic mechanisms in the cough reflex.
- Analysis of the vagal reflex tracheal constriction in the dog.
- Induction of physical dependence on codeine in the rat by drug-admixed food ingestion.
- Antitussive effect of RU-20201 - Central and peripheral actions.
- Effects of methysergide on the cough reflex.
- The role of vagal reflex in mechanism of secretagogic action of bromhexine.
- Induction of physical dependence on morphine in mice by the drug-admixed food method.
- Involvement of inhibitory innervation in reflex tracheal dilatation induced by lung inflation.
- Effects of bromhexine on the secretions of saliva and tears.
- Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats.
- Inhibitory modulation on the reflex tracheal constriction induced by afferent vagal stimulation.