PARTICIPANT OF SEROTONIN TURNOVER RATE IN THE BRAIN ON BARBITAL WITHDRAWAL CONVULSION
スポンサーリンク
概要
- 論文の詳細を見る
The correlation between the development of barbital (B)-withdrawal signs and alterations in the metabolism of brain 5-hydroxy-tryptamine (5-HT) was studied. Barbital (B)-dependent rats were prepared by the B-Admixed Food method (DAF method). The B-dependent rats were grouped according to the following 5 states: G-I, B-dependent state; G-II, B-withdrawan state; G-III, cross-administration of nitrazepam (NZP) following B-withdrawal; G-IV, cross-administration of chlorpromazine (CPZ) following B-withdrawal; and G-V, cross-administration of phenytoin following B-withdrawal. The controls were comprised of naive rats (G-VI) and naive rats dosed in the same manner as the dependent rats. The brain 5-HT synthesis rate and the brain 5-hydraxyindole acetic acid (5-HIAA) elimination were measured at 44 to 48 hr after B-withdrawal in all groups (when withdrawal convulsion was still persisting in the B-withdrawn rats of the G-II group). The brain 5-HT synthesis rate was elevated significantly (P<0.001 ) in the rats with persistent B-withdrawal convulsion (G-II) as compared with that in the B-dependent rats (G-I). Cross-administration of nitrazepam caused the elevation of 5-HT synthesis rate with B-withdrawal to be inhibited to the dependent level in parallel with the inhibition of B-withdrawal signs. On the other hand, CPZ and phenytoin, which inhibit B-withdrawal convulsion slightly, failed to recover completely the 5-HT turnover rate during B-withdrawal. From these results, it is obvious that the elevation of the brain 5-HT synthesis rate with B-withdrawal plays an important role in eliciting B-withdrawal convulsion.
- 社団法人 日本薬理学会の論文
著者
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Nakao Kenzo
Department Of Biochemistry Kyoto Pharmaceutical University
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Urano Tomoko
Department Of Pharmacology Hoshi College Of Pharmacy
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HIRAMORI Tameo
Department of Pharmacology, Hoshi College of Pharmacy
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Yanaura Saizo
Department Of Applied Pharmacology School Of Pharmacy Hoshi University
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Tagashira Eijiro
Department Of Pharmacology Hoshi College Of Pharmacy
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Tagashira Eijiro
Department Of Pharmacology School Of Pharmacy Hoshi University
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