Purification of the multifunctional calmodulin-dependent protein kinases from lung and liver, and the comparison to the brain enzyme.
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概要
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We purified the multifunctional calmodulin-dependent protein kinases (calmodulin-kinase) from rat lung and rabbit liver, and compared the properties of this enzyme with those of the rat brain enzyme. The lung and liver enzymes had molecular weights (Mr's) of 530, 000 and 330, 000 with main subunits of 52 and 51 kDa, respectively. Although the lung and liver enzymes cross-reacted with antibodies to the brain enzyme, the immunoreactivity of the lung enzyme was weaker. The substrate specificity of the three enzymes showed differences in the relative reaction rate of phosphorylation. The patterns of phosphopeptides of the lung and liver enzymes were similar to each other and only partly common to that of the 60-kDa subunit of the brain enzyme.
- 公益社団法人 日本薬理学会の論文
著者
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Fukunaga Kohji
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Tohoku University
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Miyamoto Eishichi
Department Of Electrical Engineering And Bioscience Graduate School Of Science And Engineering Wased
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Okamura Hitoshi
Department Of Anatomy And Brain Science Kobe University School Of Medicine
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Nishimura Hiroshi
Department Of Applied Chemistry Faculty Of Engineering Osaka Institute Of Technology
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NISHIMURA Hiroshi
Department of Obstetrics and Gynecology, Kumamoto University Medical School
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