Involvement of calcium in the release of immunoreactive .BETA.-endorphin-like peptide from dispersed cells of the neurointermediate lobe of the rat pituitary gland.
スポンサーリンク
概要
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The presence of Ca<SUP>2+</SUP> in the incubation medium was required for stimulation of the release of the immunoreactive β-endorphin-like peptide (IR-β-EP) from the dispersed cells of the neurointermediate lobe of rat pituitary gland by adenosine 3', 5'-monophosphate (cAMP) analogs, a phosphodiesterase inhibitor, L-isoproterenol, cholera toxin and forskolin. The basal release observed in the absence of the stimulants was also dependent on the addition of Ca<SUP>2+</SUP>. A calcium antagonist (verapamil) inhibited the effects of the stimulants. A calcium ionophore (A23187) enhanced the release of IR-β-EP, but did not stimulate the formation of cAMP. These findings suggest that Ca<SUP>2+</SUP> has the essential role in the release of β-endorphin from the neurointermediate lobe of rat pituitary gland.
- 公益社団法人 日本薬理学会の論文
著者
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Miyamoto Eishichi
Department Of Electrical Engineering And Bioscience Graduate School Of Science And Engineering Wased
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SAKODA Yoshio
Department of Obstetrics and Gynecology, Kumamoto University Medical School
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Maeyama Masao
Department Of Obstetics And Gynecology Kumamoto University Medical School
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Munemura Masahide
Department Of Obstetrics And Gynecology Kumamoto University Medical School
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Sakoda Yoshio
Department Of Obstetrics And Gynecology Kumamoto University Medical School
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FURUKI Yoshihiro
Department of Obstetrics and Gynecology, Kumamoto University Medical School
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HATADA Yasuyuki
Department of Obstetrics and Gynecology, Kumamoto University Medical School
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- Involvement of calcium in the release of immunoreactive .BETA.-endorphin-like peptide from dispersed cells of the neurointermediate lobe of the rat pituitary gland.