IMMUNOLOGICAL STUDIES OF HUMAN ENDOMETRIUM : SUPPRESSION OF LYMPHOCYTE MITOGENESIS BY ENDOMETRIAL EXTRACT
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概要
- 論文の詳細を見る
Inununoregulatory activity that suppresses lymphocyte mitogenesis was demonstrated in human secretory endometrial extracts (SEE). SEE markedly suppressed ^3H-thymidine (-3H-TdR) incorporation by phytohemagglutinin (PHA)-stimulated lymphocytes compared with myometrial extracts from the same donors. SEE-induced inhibition of lymphocyte response to PHA was significantly (p < 0.01) greater than that in cultures containing proliferative endometrial extracts at equivalent concentrations.SEE inhibited PHA- and ConA-stimulated cultures much better than PWM cultures, suggesting that it suppressed mitogen stimulation of T cells, but probably not B cells.Investigation of the kinetics of SEE-mediated suppression revealed that it vias effective in inhibiting the initial activation processes of T-cell mitogenesis.Preincubation of lymphocytes with SEE followed by washing prevented inhibition of PHA-stimulated proliferation, indicating that the inhibitory effect of SEE might be reversible.The results are discussed with respect to a possible role of the inhibitory factor(s) in SEE in facilitating the implantation process of fetal allograft.
- 社団法人日本産科婦人科学会の論文
- 1986-07-01
著者
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Maeyama Masao
Department Of Obstetics And Gynecology Kumamoto University Medical School
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Fujisaki Shunichi
Department Of Obstetics And Gynecology Kumamoto University Medical School
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