PROGESTERONE METABOLISM BY HUMAN FETAL AND PLACENTAL TISSUES: INTERCONVERSION OF PROGESTERONE AND 20α-HYDROXYPREGN-4-EN-3-ONE IN THE FETO-PLACENTAL UNIT <I>IN VITRO</I>
スポンサーリンク
概要
- 論文の詳細を見る
The metabolism of progesterone in the feto-placental unit <I>in vitro</I> was studied. Homogenates of four fetal livers (after 22-28 weeks gestation) were incubated with progesterone-4-<SUP>14</SUP>C with an NADPH generating system, and a large amount of 20α-hydroxypregn-4-en-3-one and smaller amounts of 5β-Apregnane-3α-o1-20-one and 5β-pregnane-3α, 20α-diol were identified. It is therefore considered that the major pathway of progesterone metabolism was: progesterone→20α-hydroxypregn-4-en-3-one, and that the activity of Δ4-3-keto steroid hydrogenase in fetal liver was significantly lower than after birth. The conversion of 20α-hydroxypregn-4-en-3-one to progesterone was shown to take place <I>in vitro</I> in a homogenate of human placenta with added NADP. These results suggest that the interconversion of progesterone and 20α-hydroxypregn-4-en-3-one occurs in the feto-placental unit, permitting the reutilization of progesterone which is indispensable for maintenance of pregnancy.
- 社団法人 日本内分泌学会の論文
著者
-
Maeyama Masao
Department Of Obstetics And Gynecology Kumamoto University Medical School
-
MAEYAMA MASAO
Department of Obstetrics and Gynecology, Nara Medical College
-
IKEMOTO MASANORI
Department of Obstetrics and Gynecology, Nara Medical College
関連論文
- The Effects of Sex Steroids on Blood Pressure in SHR and Normotensive Wistar Rats
- MALIGNANT DEGENERATION OF BENIGN CYSTIC TERATOMA OF THE BILATERAL OVARIES : ADENOSQUAMOUS CARCINOMA IN THE RIGHT TUMOUR AND SQUAMOUS CARCINOMA IN THE LEFT TUMOUR
- FETAL BLOOD VELOCITY WAVEFORMS IN UNCOMPLICATED PREGNANCY
- PRIMARY MALIGNANT MELANOMA OF THE VULVA ASSOCIATED WITH PREGNANCY : CLINICAL, LIGHT AND ELECTRON MICROSCOPIC OBSERVATIONS
- CLEAR CELL CARCINOMA AND ENDOMETRIOID CARCINOMA ARISING IN A ENDOMETRIOTIC CYST OF THE OVARY
- IMMUNOLOGICAL STUDIES OF HUMAN ENDOMETRIUM : SUPPRESSION OF LYMPHOCYTE MITOGENESIS BY ENDOMETRIAL EXTRACT
- Unconjugated Estradiol, Estriol and Total Estriol in Maternal Peripheral Vein, Cord Vein, and Cord Artery Serum at Delivery in Pregnancies with Intrauterine Growth Retardation
- Regulation by estrogen and progesterone of protein kinases in rabbit myometrium.
- Dissociation of alterations in levels of myosin light chain kinase and cyclic AMP-dependent protein kinase in rabbit myometrium during pregnancy.
- PROGESTERONE METABOLISM BY HUMAN FETAL AND PLACENTAL TISSUES: INTERCONVERSION OF PROGESTERONE AND 20α-HYDROXYPREGN-4-EN-3-ONE IN THE FETO-PLACENTAL UNIT IN VITRO
- Effect of Sodium Chloride on Blood Pressure Regulation and Fetal Development in Rats
- Involvement of calcium in the release of immunoreactive .BETA.-endorphin-like peptide from dispersed cells of the neurointermediate lobe of the rat pituitary gland.