Current Studies on a Working Model of CaM Kinase II in Hippocampal Long-Term Potentiation and Memory
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概要
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There have been recent advances in understanding the molecular basis of the long-term potentiatiion (LTP) of synaptic transmission in the hippocampus. This review documents current views on mechanisms underlying LTP induction, from activation of the NMDA receptor to stimulation of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). We will focus in particular on recent findings of how CaM kinase II encodes the frequency of synaptic usage and serves as a molecular memory switch at the synapse. Furthermore, a role for CaM kinase II in spatial learning and memory is demonstrated by recent studies using transgenic mice.
- 社団法人 日本薬理学会の論文
著者
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Fukunaga K
Kumamoto Univ. School Of Medicine Kumamoto Jpn
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Fukunaga Kohji
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Tohoku University
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Miyamoto Eishichi
Department Of Electrical Engineering And Bioscience Graduate School Of Science And Engineering Wased
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