Akt Is a Molecular Target for Signal Transduction Therapy in Brain Ischemic Insult
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概要
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Growth factors including insulin-like growth factor-1 (IGF-1) promote cell survival in ischemic brain injury. Stimulation of IGF-1 receptor coupled with tyrosine kinase activates phosphatidylinositol 3-kinase and subsequently, protein kinase B (Akt) in hippocampal neurons. Here we introduce a new approach of signal transduction therapy for brain damage occurring in ischemic insult. As has been shown for IGF-1, intracerebroventricular injection of sodium orthovanadate, a protein tyrosine phosphatase inhibitor, prior to ischemic insult blocked delayed neuronal death in the CA1 region. The neuroprotective effects of orthovanadate and IGF-1 were associated with an increased Akt activity in the CA1 region. We discuss here potential targets for Akt relevant to such neuroprotective activity. Our findings lead to the conclusion that Akt activity is a potential target for neuroprotective drugs in brain ischemic insult and other episodes of excitotoxic neuronal apoptosis such as seizure and Huntington’s and Parkinson’s diseases.
- 2003-08-01
著者
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Fukunaga Kohji
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
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KAWANO Takayuki
Department of Neurosurgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Grad
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Fukunaga Kohji
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Tohoku University
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Fukunaga Kohji
Department Of Pharmacology Tohoku University Graduate School Of Pharmaceutical Sciences
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Kawano Takayuki
Department Of Neurorsurgery Kumamoto University School Of Medicine
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Kawano Takayuki
Department Of 2nd Oral Surgery Osaka University Dental School
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Kawano Takayuki
Departemtn of Neurorsurgery, Kumamoto University School of Medicine
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