毛細リンパ管を中心とする鼻茸の微細構造

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Nasal polyps are usually classified into three groups according to the light microscopic observation: edematous, fibrous and ductal types. Histochemically the stroma is composed of acidomucopolysaccharides. Although the principal etiologic agents have been believed to be inflammatory or allergic in character, circulation disorder that is associated with dysfunction of the innervation in blood capillaries and congestion of lymph caused by disorder of. lymphatic capillaries can also be considered.In the present study we have ultrastructurally observed lymphatic capillaries, blood capillaries, infiltrating cells and epithelium of cysts by using an electron microscope.Materials and MethodsThe materials were obtained from patients by surgical removal. The specimens were immediately fixed in 2.5% glutaraldehyde, postfixed in 1% OSO4 and then embedded in Epon 812. ObservationsEdematous type polyps were most frequently found. In this stroma, some fibroblasts, loose collagen fibers and infiltration of lymphocytes, eosinophils and mast cells were observed.Intercellular space of lymphatic endothelium frequently opened wide with leakage seen therein.Blood capillaries were unremarkable and nerve endings were not noted around blood capillaries.In the fibrous type, infiltration of fibroblasts were prominent and collagen fibers increased in number. Intercellular space of lymphatic endothelium was relatively closed in, and anchoring filaments were observed subjacent to endothelium.In the ductal type, some mixed glands with numerous granules were seen and cyst formations were occasionally found. Epithelium of cysts was composed of a few layered squamous cells containing a great number of mitochondria and a few granules.Tne lumen was filled with amorphous material.
社団法人日本耳鼻咽喉科学会の論文

毛細リンパ管を中心とする鼻茸の微細構造

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