Effects of Microinjections of GABA Antagonist and Agonist into the Periaqueductal Gray on Electrically Induced Vocalization in Decerebrate Cats

概要

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To investigate whether GABAergic inhibition plays a major role in controlling vocalization at the periaqueductal gray (PAG), we investigated changes of the stimulus thresholds of electrically induced vocalization following injections of a GABA antagonist, bicuculline methiodide (BIC) and GABA-a agonist, muscimol into the caudal portion of the ventrolateral PAG. BIC injections into the PAG decreased the stimulus thresholds of the pontine call site (PCS) and the injection sites for about 1 hr with a similar time course, while muscimol injections increased the stimulus thresholds. BIC or muscimol injection into the areas between the PAG and the PCS, where electrical stimulation could induce vocalization, did not affect the stimulus threshold of both the PAG and the PCS. These results suggested that GABAergic inhibition modulates the mechanism of producing vocalization in the ventrolateral PAG and that the descending fibers for vocalization from the PAG passed through the PCS.
The Japan Laryngological Associationの論文