Intracellular Sodium Concentration in Diabetic Rat Ventricular Myocytes
スポンサーリンク
概要
- 論文の詳細を見る
We measured intracellular Na+ concentration ([Na+]i) of diabetic rat ventricular myocytes using sodium-binding benzofuran isophthalate (SBFI). We used diabetic rats at 8 weeks after the injection of streptozotocin (45mg/kg i.v.). The level of [Na+]i during the control perfusion was significantly lower in diabetic myocytes than that in normal myocytes (9.2±0.4mM v.s. 12.0±0.3 mM, p<0.01). After the 40min perfusion of 1μM hexamethylene amiloride (HMA), [Na+]i decreased significantly in both groups. However, there was no difference in [Na+]i between the two groups after the perfusion of HMA. It was suggested that the lower [Na+]i in diabetic myocytes could be due to the decreased activity of Na+/H+ exchange system. (Jpn Heart J 36: 647-656, 1995)
- Japanese Heart Journal Vol.36 , No.5(1995)pp.647-656の論文
著者
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OHNO Ryuzo
Third Department of Internal Medicine, Hamamatsu Medical School
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Katoh Hideki
Third Department of Internal Medicine, Hamamatsu University School of Medicine
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Satoh Hiroshi
Third Department of Internal Medicine, Hamamatsu University School of Medicine
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Terada Hajime
Third Department of Internal Medicine, Hamamatsu University School of Medicine
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Hayashi Hideharu
Photon Medical Research Center Hamamatsu University School Of Medicine
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Yamazaki Noboru
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Terada Hajime
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Satoh Hiroshi
Third Department Of Internal Medicine
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NODA Naohisa
Third Department of Internal Medicine, Hamamatsu University School of Medicine
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OHNO Ryuzo
Third Department of Internal Medicine, Hamamatsu University School of Medicine
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