Effect of Nitroglycerin on the Free Radical Formation of Myocardial Mitochondria Impaired by Ethanol : Studies by Electron Spin Resonance (ESR) Spectrometry
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概要
- 論文の詳細を見る
In order to investigate the direct metabolic effect of nitroglycerin on myocardium, its effect on mitochondrial free radical formation was studied in vitro, using the dog heart mitochondria impaired by ethanol. Free radical concentrations in state 4 respiration or the ratio of free radical concentrations in state 4 to state 1 was used as an index of mitochondrial function. Free radical concentrations were represented as ESR intensity.In normal control, ESR intensity increased from 0.115±0.030 (mean±SD) per mg protein in state 1 to 0.178±0.017 in state 4 (p<0.001). When mitochondria were treated with 10-4M ethanol, on the other hand, ESR intensity decreased from 0.163±0.34 in state 1 to 0.137±0.019 in state 4 (p<0.05). When mitochondria were treated with 10-6M nitroglycerin, in spite of the presence of 10-4M ethanol, ESR intensity increased from 0.124±0.23 in state 1 to 0.153±0.024 in state 4 (p<0.05). ESR intensity in state 1 was increased by the treatment of ethanol (p<0.05), whereas ESR intensity in state 4 was decreased (p<0.001), and these effects were prevented by nitroglycerin (p<0.05). The ratio of ESR intensity in state 4 to state 1 demonstrated more remarkably the effects of ethanol and nitroglycerin. Ethanol reduced the ratio from 1.65±0.47 in the control to 0.86±0.13 (p<0.001) and the reduction was prevented by nitroglycerin to 1.25±0.23 (p<0.01).It is concluded that nitroglycerin prevented the impairment of free radical formation of the mitochondria induced by ethanol, presumably by a mitochondrial membrane-stabilizing action
- International Heart Journal刊行会の論文
著者
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Suzuki Yoshikazu
Third Department of Internal Medicine, Hamamatsu University School of Medicine
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Yamazaki Noboru
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Suzuki Yoshikazu
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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YAMAMOTO Mitate
Third Department of Internal Medicine, Aichi Medical University
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Suzuki Yoshikazu
The 2nd Dept. Of Intern Med. Nagoya Univ. School. Of Med.
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Kamikawa Tadashi
Third Department Of Internal Medicine Aichi Medical University
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YAMAMOTO Mitate
Third Department of Internal Medicine, Aichi Medical College
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