A Study on the Noninvasive Evaluation of Coronary Vasodilating Drugs with Thallium-201 Myocardial Imagings

概要

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To evaluate clinically the effects of coronary vasodilating drugs, isosorbide dinitrate (ISDN), dilazep (DL), and dipyridamole (DP), on the myocardial perfusion, quantitative analysis of Thallium-201 myocardial imagings was performed before and after their sublingual or oral administration in 17 patients with ischemic heart disease (IHD) and 9 normal volunteers.The ratio of total myocardial blood flow to cardiac output (TMBF/CO) and the ratio of ischemic regional myocardial blood flow to cardiac output (RMBF/CO) were calculated according to the indicator fractionation principle. The ratio of radio-activity of infarcted region to total myocardium (R/T) was also calculated to judge the degree of scintigraphic defect objectively.There were increases in TMBF/CO in 7 of 9 patients after ISDN, 4 of 5 patients after DL, and 2 of 6 patients after DP. Increases in RMBF/CO were observed in all patients studied after ISDN and DL, whereas in 2 of 6 patients after dipyridamole. Decreases both in RMBF/CO and R/T which suggest coronary steal phenomenon were observed in 4 of 6 patients after DP.The myocardial imaging technic is a useful noninvasive method for clinical evaluation of coronary vasodilating drug.
International Heart Journal刊行会の論文